A Double-blinded Randomised Evaluation of Alfentanil and Morphine versus Fentanyl: Analgesia and Sleep Trial.

In post-operative patients, is a combination of alfentanil and morphine as good as or better than fentanyl at providing analgesia adequate to prevent pain-related waking from sleep.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000118303

Acronym

DREAMFAST

Enrollment

200

Registered

2008-03-05

Start date

2008-04-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Combined alfentanil 0.075mg and morphine 1.0 mg per ml of solution, administered by patient via Patient Controlled Intravenous Analgesia (PCIA) device programmed to deliver 1ml boluses with a 5 minute lockout, for 2 nights or until conversion to oral analgesia is appropriate.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients scheduled to undergo inpatient surgery where Patient-Controlled Intravenous Analgesia is indicated post-operatively, who are capable of providing informed consent, understanding how to use the PCIA device and activating the PCIA device.

Exclusion criteria

American Society of Anesthesiologists (ASA) Physical status 4 or 5, renal or hepatic failure, obstructive sleep apnoea requiring treatment, allergy to morphine, alfentanil or fentanyl, history of opioid abuse or chronic opioid use, inability to use the PCIA device, inability to complete the questionnaire, use of a continuous regional analgesic technique, previous participation in this trial.

Outcome results