Fish oil and hip fracture

Effect of n-3 fatty acids on outcomes following hip fracture: a pilot study to investigate proof of concept, feasibility of recruitment and adherence to a 6 week fish oil intervention.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000099325

Enrollment

Registered

2008-02-21

Start date

2008-03-03

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Inflammatory markers have been found to be raised in hip fracture patients. It is plausible that fish oils will counteract production of these chemicals and reduce weight and muscle loss which is experienced in many of these patients. This study will investigate proof of this concept, feasibility of recruitment and adherence to fish oil liquid or capsules.

Interventions

6 week fish oil intervention (15ml/day liquid fish oil (4.9g EPA) OR 9 fish oil capsules/day (4.8g EPA)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

60 years or over Hip fracture sufferers No cognitive impairment according to the Mini Mental State Examination (MMSE score over 24/30) At risk of subsequent weight loss according to the Simplified Nutrition Appetite Questionnaire (SNAQ score less than or =14/20) Elevated CRP (6mg/L or more) Able to consent

Exclusion criteria

Allergy to fish Initiation of anti-inflammatory corticosteroids within the prior two weeks Ingestion of n-3 fatty acid supplements within four weeks of study initiation Life expectancy less than 6 weeks

Outcome results