Post Amputation Phantom Limb Pain Study

Can Pregabalin prevent persistent post amputation pain?

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000088347

Enrollment

120

Registered

2008-02-15

Start date

2008-03-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of the study is to determine whether the use of the drug Pregabalin can reduce or eliminate phantom pain after leg amputations

Interventions

One month course of oral pregabalin commencing with a single preoperative 150md dose of pregabalin, followed by 75mg oral pregabalin BD for 7 days after surgery, then increasing to 75-150mg bd for the following 21 days, a total of 28 days of pregabalin

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patient able to provide own informed consent. there is sufficient ime before proposed surgery to allow absorption of loading dose of pregabalin, minimum 2hrs Patient is suitable for standard general anaesthetic (GA) regimen and able to use patient controlled analgesia (PCA) for postop analgesia

Exclusion criteria

Current use of gabapentin Unable to give consent epilepsy pregnancy lactation significant renal impairment galactos metabolic disorders

Outcome results