Effects of tetrahydrobiopterin(BH4) in patients with angina

Effects of tetrahydrobiopterin (BH4) on myocardial blood flow and vascular function in coronary artery disease.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000087358

Enrollment

Registered

2008-02-14

Start date

2008-01-02

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of the study is to evaluate the effect of tetrahydrobiopterin (BH4) on myocardial blood flow and vascular function in patients with coronary artery disease.

Interventions

Folic acid (20 mg/day) and tetrahydrobiopterin (5 mg/kg/day) for 14 days

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

stable angina

Exclusion criteria

renal failure, unsuitable for Magnetic Resonance Imaging

Outcome results