Malnutrition, fuel utilisation and nocturnal carbohydrate supplementation in cirrhosis.

Fuel utilisation in people with cirrhosis measured by indirect calorimetry after nocturnal supplemention with complex carbohydrates compared to nocturnal supplementation with a high-energy, high-protein drink.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12608000021370

Enrollment

Registered

2008-01-16

Start date

2008-01-30

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We aim to increase the understanding of how nutrition supplements interact with metabolism and fuel usage in advanced liver disease. The objective of this study is to investigate the impact of three different nutrition supplements on metabolic rate and fuel usage in people with cirrhosis. It is hypothesised that a cornflour supplement taken in the evening will improve fuel usage, as measured by indirect calorimetry, for cirrhotic patients compared to an evening snack that is nutritionally similar but without cornflour.

Interventions

This is a repeated measures study where all participants will be in all conditions. There are 3 study visits with a washout period of 6 nights between visits. The study supplement is given on one occasion only the night before Visit 3. The study supplement consists of 350ml low fat soy milk with 3 tbspns cornflour, 16g Poly-joule powder (glucose polymer, Nutricia).

Study design

Allocation

Non-randomised trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

17 Years to 65 Years

Healthy volunteers

Inclusion criteria

Cirrhosis

Exclusion criteria

Conditions that alter fuel utilisation and energy expenditure such as malignancy.

Outcome results