None listed
Conditions
Brief summary
The primary aim of this study is to discover if giving patients with severe kidney failure ascorbate (vitamin C) reduces symptoms that are common to both renal failure and ascorbate deficiency. It is known that low ascorbate levels are common in patients with severe kidney failure, and that symptoms of scurvy (ascorbate deficiency) and of kidney failure (uraemic syndrome) overlap. There is however no consensus on whether ascorbate supplementation is beneficial in patients with severe kidney disease and there are concerns that supplementation may cause adverse effects. This study would significantly improve clinical care, by examining the benefits and adverse outcomes of supplementation.
Interventions
Oral ascorbic acid 250mg three times a week for 3 months from when subject is first enrolled into the study
Sponsors
The Canberra Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Receiving maintenance dialysis treatment OR estimated Modification of Diet in Renal Diseases Glomerular Filtration Rate (MDRD GFR) of less than 20ml/min
Exclusion criteria
Life expectancy less than 3 months Primary hyperoxaluria Clinically unstable Unable to provide informed consent Unwilling to cease non study ascorbate containing supplements Not fluent in English
Outcome results
None listed