Canterbury anti-neutropil cytoplasmic antibody (ANCA) associated vasculitis observational study

Long-term disease outcomes including organ damage and predictors of disease flare in anti-neutropil cytoplasmic antibody (ANCA) associated vasculitis

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12608000012370

Enrollment

Registered

2008-01-10

Start date

2008-01-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Wegener’s Granulomatosis (WG) and WG-like diseases affect the small/medium sized blood vessels. In Canterbury the prevalence of WG is one of the highest in the world. Despite this, we are reliant on information from the Northern Hemisphere to guide us on outcomes and treatments. Whether there are differences in disease severity, prognostic markers and treatment response between the Northern and Southern Hemispheres is unknown. We wish to undertake an observational study of WG patients in Canterbury to characterise the clinical characteristics, treatments and outcomes and compare them to those in the Northern Hemisphere. In addition we will evaluate whether novel markers in the blood and urine help predict disease relapse. Although WG is a rare condition, the severity, chronicity and treatments have a significant impact on those affected. The ability to better predict disease relapse will potentially avoid exposure to harmful treatments.

Interventions

ANCA associated vasculitidies are rare conditions with significant morbidity. We will observe patients indefinitely to determine long-term disease outcomes and predictors of disease relapse

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

ANCA associated vasculitis defined by American College of Rheumatology (ACR), Chapel Hill Consensus Criteria or Watts 2007 algorithm

Exclusion criteria

Unable to provide informed consent

Outcome results