None listed
Conditions
Brief summary
It is routine clinical practice to administer high flow oxygen to patients with a heart attack or angina; however, there is some evidence to suggest that this approach may be harmful, especially in patients who are not hypoxic. This single group interventional trial aims to test this by recruiting 50 inpatients from the coronary care unit at Wellington Hospital who have confirmed coronary disease and a history of angina at rest or with minimal exertion. Subjects will receive high flow oxygen for 30 minutes. Subjects will be monitored to establish if angina occurs during the oxygen administration and if so how soon after it starts. ECGs will be taken throughout the study to monitor for any significant changes.
Interventions
High flow oxygen (administered as 15L/min via a non-rebreather mask for 30 minutes)
Sponsors
Medical Research Institute of New Zealand
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Current inpatients on the cardiac care unit (CCU) Wellington Hospital; confirmed diagnosis of coronary disease on angiography; experiencing chest pain (at rest or with minimal exertion) considered by CCU staff to be consistent with angina.
Exclusion criteria
Patients with chest pain at the time of enrolment; diagnosis of severe Chronic Obstructive Pulmonary Disease (COPD) or emphysema; room air oxygen saturations less than 92%; presence of bundle branch block pattern on resting ECG; patients requiring intravenous nitrates; glyceryl trinitrate use in the previous 2 hours.
Outcome results
None listed