None listed
Conditions
Brief summary
Cardiac surgery triggers an acute inflammatory response throughout the body that contributes to multiple organ failures. How this inflammatory response causes organ failures is not well understood. We have undertaken trials that demonstrate the formation of clots in small blood vessels (capillaries) maybe an important mechnanism.We would like to further investigate this mechanism of organ injury by studying the capillaries in the back of the eye (retina) to see if clots form there following cardiac surgery. Unlike other parts of the body the capillaries of the retina can be seen using fundoscopy ( a special torch that focuses light on the retina). We will use a fundoscopic camera to take pictures of the retina before and after cardiac surgery to asses the changes in the capillaries. Taking pictures of the back of the eye will not expose patients to any risks. The results of this trial may highlight a new and important mechanism of organ injury in inflammatory states.
Interventions
Right pupil will be dilated with 1 drop of 0.1% tropicamide eye drops. Retinal and macular photographs will be taken pre-operatively and post-operatively
Sponsors
St Vincents Hospital
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients undergoing cardiac surgery
Exclusion criteria
Previous cardiac surgery; eye disease; patient refusal; type 1 Diabetes Mellitus
Outcome results
None listed