Modulation of systemic reaction to operation in liver surgery: A prospective randomised study on the Impact of preoperative steroids administration on systemic responses to liver surgery

Impact of preoperative steroids administration on surgical stress in patients undergoing liver surgery

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000605493

Acronym

MIRP002

Enrollment

120

Registered

2007-11-26

Start date

2005-04-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Preoperative steroid administration may represent a safe and effective modulator of surgical stress, may reduce hepatic ischemia reperfusion injury, maintain coagulant/anticoagulant homeostasis, and reduce postoperative complication by modulating the inflammatory response.

Interventions

Single Intravenous Administration of 500 mg of methylprednisolone at the induction of anaesthesia. Several markers of surgical stress, liver function and coagulation were evaluated for 5 days after the surgical procedure. Postoperative complication were evaluated until post operative day 30.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to -2147483648 No limit

Healthy volunteers

Inclusion criteria

Patients undergoing liver surgery for benign and malignant disease

Exclusion criteria

-Concomitant extrahepatic surgery -Intraoperative radiofrequency -Suspected active infective disease

Outcome results