Metabolic Effects of SERMs (Selective Oestrogen Receptor Modulators) in healthy men and healthy postmenopausal women

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000586415

Enrollment

Registered

2007-11-16

Start date

2006-11-27

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We aim to investigate and compare the effects of raloxifene and tamoxifen (two most commonly used SERMs) in healthy men and women on the growth hormone system and metabolism.

Interventions

Raloxifene 60mg and 120 mg daily and Tamoxifen 10 mg and 20 mg daily. Duration of treatment for each dose is 2 weeks with washout period of 2 weeks after cross over.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Educational / counselling / training

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy postmenopausal women and healthy men the same age

Exclusion criteria

obesity, diabetes, cancer, kidney or liver diseases, deep vein thrombosis

Outcome results