None listed
Conditions
Brief summary
This project aims to determine the dose-response effect of low doses of long chain omega-3 polyunsaturated fatty acids on plasma triglyceride levels in pre-menopausal women with mildly elevated triglycerides. The dose-response effect on plasma lipoprotein levels and particle size, as well as omega-3 levels in various blood samples (plasma, erythrocytes, whole blood from fingertip) will also be investigated.
Interventions
This is a dose-response study therefore participants will be randomized to one of 4 dose groups (0, 0.3, 0.7 or 1.0g/day) of long chain omega-3 fatty acids (Nu-Mega DHA-rich tuna oil capsules, 500mg).
Duration is 2 menstrual cycles (approximately 8 weeks).
0.3g/day group consumes 2 tuna oil capsules and 4 placebo capsules per day; the 0.7g/day group consumes 4 tuna oil capsules and 2 placebo capsules per day; and the 1.0g/day group consumes 6 tuna oil capsules per day. These 3 dose groups will b
This is a dose-response study therefore participants will be randomized to one of 4 dose groups (0, 0.3, 0.7 or 1.0g/day) of long chain omega-3 fatty acids (Nu-Mega DHA-rich tuna oil capsules, 500mg). Duration is 2 menstrual cycles (approximately 8 weeks). 0.3g/day group consumes 2 tuna oil capsules and 4 placebo capsules per day; the 0.7g/day group consumes 4 tuna oil capsules and 2 placebo capsules per day; and the 1.0g/day group consumes 6 tuna oil capsules per day. These 3 dose groups will be compared to 1 placebo group which consumes 6 placebo capsules per day (Sunola oil).
Sponsors
University of Wollongong
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Female, generally healthy, regular menstrual cycles, plasma triglycerides >1.0mmol/L at screening visit.
Exclusion criteria
Pregnant, irregular menstrual cycles, anemia, or plasma triglycerides < 1mmol/L at screening visit.
Outcome results
None listed