None listed
Conditions
Brief summary
The primary purpose of the present study was to use spatial ICA to identify differences in the resting-state functional connectivity of the fronto-striatal-insular network between healthy controls and patients with ADHD. We hypothesize that the pathophysiology of ADHD involves dysfunctional interaction or connectivity among regions of the fronto-striatal-insular network. ICA was used to calculate spatially independent, temporally synchronous regions (i.e., network) (Calhoun et al 2004); the fronto-striatal-insular network for each subject was selected using a spatial template to identify the network of interest. Study hypotheses were then tested by comparing the spatial-temporal characteristics of the fronto-striatal-insular network within and between groups.
Interventions
The goal of this study was to examine the resting-state functional connectivity within the fronto-striatal-insular network in subjects with ADHD and in healthy controls. Twenty-nine boys with ADHD engaged in resting-state fMRI scanning for 8 minutes during which they were instructed to lie with their eyes closed, think of nothing systematically, and not fall asleep.
Sponsors
the NSFC Chinese-Finnish NEURO program
Eligibility
Sex/Gender
Male
Age
11 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
1) right-handed, 2) Combined subtype of Attention Deficit/Hyperactivity Disorder (ADHD-C) or Attention Deficit/Hyperactivity Disorder predominantly inattentive type (ADHD-I)) and normal controls, 3) no history of emotional disorders, affective disorders, Tourette disorder and other Axis?psychiatric disorder.
Exclusion criteria
The full scores of Wechsler Intelligence Scale for Chinese Children-Revised lower than 85.
Outcome results
None listed