None listed
Conditions
Brief summary
Exercise is used to make a diagnosis of exercise induced bronchoconstriction (narrowing of the airways) in children and adults with a history of breathlessness during or after exertion. We are aiming to find out how much change in exhaled nitric oxide occurs after exercise and whether the amount of exhaled nitric oxide is related to exercise induced cough.
Interventions
Randomised to either exercise challenge as per American Thoracic Society guidelines on first day or inhaled dry powder mannitol challenge (potentially 635mg). Second day the challenge not undertaken on day 1 will be undertaken, ie. cross-over design.
The testing is completed over 2 consecutive days, however a diary card is completed over a 28 day period, 4 days prior to testing and a further 24 days post testing.
Sponsors
Helen Petsky
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
Children aged >6 years with a cough (either inpatients or outpatients) Controls: Well children >6 years without cough.
Exclusion criteria
Children unable to perform exercise test or breathing test
Outcome results
None listed