None listed
Conditions
Brief summary
Hypothesis/research questions: That mothers can be effectively coached on a number of simple measures that will improve skin barrier function in their infants that will reduce the incidence of Atopic Dermatitis And that improvement in skin barrier function will reduce the incidence and severity of atopic dermatitis in the short term and ultimately, food allergy and asthma associated with atopic dermatitis And that null mutations in the fillagrin gene increase the risk of future development of atopic dermatitis, food allergy and asthma associated with atopic dermatitis. And that null mutations in the fillagrin gene are predictive of infants who stand to obtain the greatest benefit from interventions to improve skin barrier function. To test our hypothesis we propose to conduct a prospective randomised controlled study. The study will investigate the impact of a number of simple intervention measures on epidermal barrier protection as measured by transepidermal water loss in infants and young children. In addition, this randomized, controlled study will measure the prevalence and severity of atopic dermatitis.
Interventions
The below intervention will be advised to the parents to follow in their babies for a period of 5 years.
Telephone contact for approximately 20 minutes will occur at weeks 1, 3, 6, 12, 26, 38, 52 and then every 6 months until the age of 5 years post-gestation.
Transepidermal water loss will be measured at 6, 12, 24 and 36 months to assess the integrity of the infants’ barrier function.
Parents will be encouraged to limit bath times to less than 5 minutes, bathe their children without soap, dete
The below intervention will be advised to the parents to follow in their babies for a period of 5 years. Telephone contact for approximately 20 minutes will occur at weeks 1, 3, 6, 12, 26, 38, 52 and then every 6 months until the age of 5 years post-gestation. Transepidermal water loss will be measured at 6, 12, 24 and 36 months to assess the integrity of the infants’ barrier function. Parents will be encouraged to limit bath times to less than 5 minutes, bathe their children without soap, detergent or bubble baths and to use an emollient after bathing. In addition mothers will be given specific advice about appropriate temperatures for ducted central heating (maximum of 19 degrees Celsius), and measures to keep cool while sleeping. The children will attend respiratory examination with spirometry and measurement of airway hyper responsiveness at age 5.
Sponsors
Fred Bauer Research Fund
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
1 Days to 5 Years
Healthy volunteers
Yes
Inclusion criteria
The babies born to the mothers with past history of Asthma will be identified and enrolled for the study
Exclusion criteria
Other congenital skin disease
Outcome results
None listed