None listed
Conditions
Brief summary
The ambulance services are conducting a project to compare the pain killing qualities of two medications, ketamine and morphine in people with moderate to severe pain following a traumatic injury. We are hoping to determine which medication is best to use when the ambulance services attend a person with an injury and are in pain.
Interventions
Ketamine Hydrochloride (Intervention) 10-20 mgs bolus Intraveneously every three minutes. Patients will continue to receive boluses of the drug until either; 1. Patient is pain free 2. Side effects develop or 3. Arrival at a receiving Emergency Department
Sponsors
Prof. Peter Cameron
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to -2147483648 No limit
Healthy volunteers
No
Inclusion criteria
Attended by participating ambulance crew Patient conscious (GCS=15), speaking and able to rate their pain using the Verbal Numerical Rating Scale (VNRS) Moderate to Severe pain due to trauma defined as VNRS of 5 or greater.
Exclusion criteria
Known allergy to ketamine hydrochloride or morphine sulphate Pregnant or lactating women Ischameic chest pain, acute pulmonary oedema and/or severe hypertension (Systolic Blood Pressure>180 mmHg) Head injury with a history of loss of consciousness or Glasgow Coma Scale<15 Inability to obtain venous access Presumed intoxication with alcohol or illicit substances
Outcome results
None listed