Fish oil in knee osteoarthritis

A randomized controlled trial in adults with knee osteoarthritis to determine the effect of high dose fish oil compared with low dose fish oil on symptomatic and structural outcomes.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000415404

Acronym

FOSTAR

Enrollment

200

Registered

2007-08-17

Start date

2007-07-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to assess the efficacy of an anti-inflammatory dose of fish oil in the treatment of knee osteoarthritis, both with regard to symptom control and progression of structural changes. These will be assessed using WOMAC questionnaire, analgesic use and knee magnetic resonance imaging (MRI).

Interventions

Liquid oral high dose fish oil 15ml per day for duration of 2 years.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

40 Years to -2147483648 No limit

Healthy volunteers

Inclusion criteria

Adults with symptomatic knee osteoarthritis, defined using American College of Rheumatology (ACR) criteria. Symptomatic knee osteoarthritis (score of >4 on at least 1 pain dimension of the Western Ontario and McMaster Osteoarthritis Index (WOMAC).

Exclusion criteria

Dementia or inability to give informed consent; grade 4 (endstage) xray changes in the symptomatic knee; planned knee joint replacement surgery; daily fish oil ingestion >=10mL or 9 standard capsules for the preceding 3 months; contra-indications to MRI.

Outcome results