Does dexamethasone influence blood cortisol levels after laparoscopic cholecystectomy?

Dexamethasone administration for postoperative nausea and vomiting in laparoscopic cholecystectomy and perioperative cortisol levels.

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000406404

Enrollment

Registered

2007-08-07

Start date

2007-09-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary endpoint of the study is to determine if dexamethasone 8mg, administered at the start of an anaesthetic to prevent postoperative nausea and vomiting, reduces the level of cortisol postoperatively. Cortisol is a hormone produced by the adrenal glands in times of stress (such as at operation). Dexamethasone is frequently used to prevent nausea and vomiting after operations and is known to reduce cortisol levels in patients not having operations.

Interventions

Dexamethasone 8mg once only intravenously at commencement of anaesthesia for laparoscopic cholecystectomy. All participants (both active and control groups) receive tropisetron 2mg intravenously at the completion of surgery. Dexamethasone and tropisetron are used to prevent postoperative nausea and vomiting.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients undergoing laparoscopic cholecystectomy with none of the exclusion criteria.

Exclusion criteria

Non English speakingInsulin requiring diabetesPatients receiving exogenous steroid treatment for other illness.Unable to receive standardised inhalational anaesthesia.

Outcome results