Salt, obesity, endothelial function and cardiovascular disease risk study 2007

A 4 week cross-over study investigating the effects of a low salt diet compared to a normal salt diet on blood pressure and vascular function.

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000381482

Acronym

Enrollment

Registered

2007-07-20

Start date

2007-10-08

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of the study is to find out what the effect of a low salt diet compared to a normal salt diet has on blood pressure and vascular function measured by ultra sound in overweight people who are at risk of heart disease.

Interventions

dietary intervention study with a low salt diet (50mmol per day)as the treatment. Volunteers will crossover to both treatments as randomly allocated with no washout between interventions.Participants are on either diet for 2 weeks, then immediately cross-over to the other intervention.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Healthy volunteers

Inclusion criteria

• 30 overweight and obese men and women (Body Mass Index 27-40kg/m2)• Systolic blood pressure between 130 and 160 mmHg will be selected. • weight stable over the previous 6 months.

Exclusion criteria

• Known metabolic disease such as liver or kidney disease, hypertension systolic Blood pressure>160 mmHg• Cardiovascular disease• Active weight loss in preceding 6 months

Outcome results