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A Study into High Flow Humidified Nasal Oxygen Therapy (OptiflowTM) and its' Impact on Lung Pressures.

A Study of Cardiac Surgical Patients Using High Flow Humidified Nasal Oxygen Therapy (OptiflowTM) and its' Impact on Mean Airway Pressures at Different Flow Rates.

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12607000372482
Enrollment
15
Registered
2007-07-16
Start date
2007-09-10
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will describe the relationship between the flow of gas delivered by the OptiflowTM system and the pressure exerted in the upper airways of 15 cardiac surgical patients. The researchers wish to demonstrate that more gas flow will deliver higher pressures to the airways.This information is needed so that doctors can be guided as to how much flow to administer to patients in order to achieve a desired airway pressure. Such pressure in the airways can assist patients who have breating difficulties. This data will also inform future, more detailed research in this area.

Interventions

Whilst participants (n15) are still sedated following cardiac surgery, a 10F pressure catheter will be inserted into the hypopharynx via the nose. Once awake and extubated, participants will be commenced on the OptiflowTM system. Once settled on the therapy the pressure catheter position will be confirmed using end tidal CO2 monitoring. Pressure measurements will then be carried out with three different gas flow rates:30, 40 and 50L/min with mouth open and then repeated with mouth closed. The pr

Whilst participants (n15) are still sedated following cardiac surgery, a 10F pressure catheter will be inserted into the hypopharynx via the nose. Once awake and extubated, participants will be commenced on the OptiflowTM system. Once settled on the therapy the pressure catheter position will be confirmed using end tidal CO2 monitoring. Pressure measurements will then be carried out with three different gas flow rates:30, 40 and 50L/min with mouth open and then repeated with mouth closed. The pressure catheter will be gently removed at the end of this period. The measurements will take approximately 30mins to complete. The intervention is OptiflowTM at three different flow rates. We are investigating only the relationship between flow and pressure. We hope to describe a positive and linear relationship between flow and pressure. ie more flow equals more pressure.

Sponsors

Fisher and Paykel Healthcare Ltd
Lead SponsorCommercial sector/Industry

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Consent has been obtained • The patient is undergoing cardiac surgery requiring sternotomy.

Exclusion criteria

Patients will be excluded from the study if one or more of the following criteria are present:• The patient has significant nasal septum deviation.• High flow nasal oxygen therapy is contraindicated. • Following surgery the patient is unable to follow simple commands once awake and extubated

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026