"A Randomised Controlled Trial on the Effectiveness of Synbiotics on the Frequency and Duration of Loose Bowel Movement in Acute Adult Diarrheal Disease.

A Randomised Controlled Trial on the Effectiveness of Synbiotics, Lactobacillus acidophilus and Bifido bifidum in Soy Phytochemical Extract, on the Frequency and Duration of Loose Bowel Movement in Acute Adult Diarrheal Disease.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000296437

Enrollment

Registered

2007-06-04

Start date

2006-09-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To determine if supplementation with the synbiotic would decrease the frequency of bowel movements of adult patients admitted for acute diarrheal disease.

Interventions

Synbiotics- is a combination of probiotics and prebiotics.this is composed of live microbial supplements and non digestible sugars that stimulate the growth of those bacteria. The soy phytochemical extract contains Lactobacillus acidophilus and Bifido bifidum given to the randomize test group 1 casule 3 times a day for 4 days per orem. One capsule of the soy phytochemical extract contains 3.5 billion viable probiotic colony forming bacteria. 1.5 billion Bifido bifidum and 1.65 billion Lactobacillus acidophilus and 100mg prebiotic soluble oligosaccharides and soy phytochemical exract. All patient were put on low fat, lactose free diet, in the entire hospital stay. All results will be collected at the end of the 6 months study period, unmask, tabulated and analyze by the authors.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Angeles University Foundation Medical Center (AUFMC) and Rafael Lazatin Memorial Medical Center (RLMMC) patients, admitted for acute diarrheal disease from September 2006 to March 2007.Acute Diarrhea is defined as loose, watery, bowel movement of more than 3x a day non-bloody; loose watery bowel movement of 2 episodes more than patient’s usual BM.

Exclusion criteria

Patients with co-morbidities, those who are diagnose with typhoid infections, amebiasis, no history or current antibiotics or antidiarrheal medication use, overflow diarrhea, antimotility intake, irritable bowel syndrome, history of diabetes mellitus, laxative abuse, malabsorption syndrome, thyroid pathology and those who are having diarrhea for more than a week.

Outcome results