None listed
Conditions
Brief summary
To determine IM olanzapine is more effectivd than haloperidol in treating acutely agitated patients in the emergency department setting
Interventions
Patients are randomized to either olanzapine or haloperidol groups. The study aim is to compare the time for sedation of acutely agitated patients in the olanzapine group (new treatment) with haloperidol group (traditional treatment). The duration of intervention is about 30 minutes after single dose of study drug. The dose of olanzapine and haloperidol are both intramuscularly 10mg. The estimated study period will be approximately one year and the sample size is approx 140 in each study group
Patients are randomized to either olanzapine or haloperidol groups. The study aim is to compare the time for sedation of acutely agitated patients in the olanzapine group (new treatment) with haloperidol group (traditional treatment). The duration of intervention is about 30 minutes after single dose of study drug. The dose of olanzapine and haloperidol are both intramuscularly 10mg. The estimated study period will be approximately one year and the sample size is approx 140 in each study group i.e. 280 subjects in total.
Sponsors
Peninsula Health (Emergency Department)
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Acute agitation that required chemical restraint.
Exclusion criteria
Readily reversible aetiology for the agitationhypotensionknown allergy to either drugvisible or suspected head traumaunable to maintain their own airwayin respiratory distressknown pregnancyknown Parkinson's disease or Lewy Body Dementiaaged
Outcome results
None listed