None listed
Conditions
Brief summary
Study design: a parallel 18-month randomised, double-blind, placebo-controlled intervention trial with repeated measures every 6 months, totalling 4 measurement points. Participants: 400 men & women, aged 65-90 years. Intervention: Half the participants will receive fish-oil capsules and the other half will receive placebo capsules for 18 months. Outcome measures: cognitive performance and cognitive change, well-being, blood pressure, oxidative stress, and inflammation. Demographic and nutritional data will be collected as covariates.
Interventions
18 month intervention of either: ACTIVE: long chain omega-3 polyunsaturated fatty acids (430mg DHA; 150 mg EPA) Participants will consume 2 capsules in the morning and 2 in the evening for 18 months.
Sponsors
Commonwealth Scientific Industrial Research Organisation
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
• fluency in the English language • agree to not commence own n-3 fish-oil (or algal) supplementation throughout the duration of the study
Exclusion criteria
• already taking n-3 fish-oil (or algal) supplements • inability to swallow capsules• physically unable to attend laboratory/use pen and paper • diagnosed with intellectual disability, clinical depression, dementia • score < 24 on the dementia screeening measure at screening, have had head injury, stroke, coronary artery bypass surgery, any known degenerative neurological disease, history of alcohol or drug abuse
Outcome results
None listed