None listed
Conditions
Brief summary
This study will investigate whether exercise training of respiratory muscles can slow the inevitable decline in respiratory function in patients with MND, and thereby improve quality of life. The hypothesis is that respiratory training will result in maintentance or improvement of respiratory and functional outcomes in patients with MND.
Interventions
The training group will complete a standardized 3 month period of respiratory training using a threshold inspiratory muscle trainer. Participants will train 3 times each day for 10 minutes each session. Training pressure will be set at a minimum target % of maximum inspiratory pressure. Participants will be trained in the use of the device and will perform daily training. Participants will be assessed every 2 weeks when training pressure will be adjusted accordingly to maintain the target pre
The training group will complete a standardized 3 month period of respiratory training using a threshold inspiratory muscle trainer. Participants will train 3 times each day for 10 minutes each session. Training pressure will be set at a minimum target % of maximum inspiratory pressure. Participants will be trained in the use of the device and will perform daily training. Participants will be assessed every 2 weeks when training pressure will be adjusted accordingly to maintain the target pressure.
Sponsors
Associate Professor Matthew Kiernan and the Prince of Wales Medical Research Institute.
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to -2147483648 No limit
Healthy volunteers
No
Inclusion criteria
Volunteers with MND diagnosed by a Neurologist, using results from neurophsyiological, and clinical examinations, and the revised El Escorial criteria. And volunteers must be able to attend the Prince of Wales Hospital, Randwick.
Exclusion criteria
Participants unable to train due to MND disease state; presence of any other co-existing significant respiratory, neurological or malignant disease processes.
Outcome results
None listed