Efficacy of intravitreal triamcinolone acetonide before pan retinal photocoagulation for improvement of visual acuity and macular edema in diabetic retinopathy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000225415

Enrollment

Registered

2007-04-30

Start date

2005-11-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Purpose was to evaluate efficacy of intravitreal triamcinolone acetonide before pan retinal photocoagulation for improvement of visual acuity and macular edema in diabetic retinopathy. Our hypothesis is that triamcinolone acetonide before PRP helps for decreasing macular edema and improvement of visual acuity

Interventions

Patients with Severe NPDR or PDR who need panretinal photocoagulation(PRP) and have macular edema with same stage in both eyes are randomized to two groups. One eye is in the injection group The other eye is active control. in the first group 4 mg triamcinolone acetonide is injected intravitreally 1 week before first session of PRP . PRP is done in 3 sessions 1 week apart.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

All diabetic patients with severe NPDR or PDR and same stage macular edema in both eyes (Have or not have CSME in both eyes).

Exclusion criteria

Tractional retinal detachment, glaucoma, corticosteroid responders, active ocular surface disease, media opacity precluding visibility of fundus details.

Outcome results