None listed
Conditions
Brief summary
This is a small simple pilot study to identify any practical and acceptability issues with conducting this kind of trial which aims to replicate the trial design of Morgan et al published in the New England Journal of medicine in 2004, which found a significant reduction in asthma symptoms days by reducing allergen levels in the home enviromnet through allergen avoidance measures that were tailored to the child's skin prick test status. In New Zealand we have a somewhat different prevalence of the kinds of allergens found in the United States and we have a much higher prevalence of childhood asthma, hence it is important to pilot the Morgan study design in the New Zealand setting before undertaking a full study.
Interventions
Allergen avoidance measures within the home environment which are tailored to the child's skin prick tests, such as allergen occlusive duvet, pillow, mattress, and bed base coverings; laundering with an acaricide; drying laundry in sunlight; pest control measures and extermination; Highly Efficient Particulate Arrestance (HEPA) filter in bedroom air filter and in vacuum cleaner; smoke-free indoor environment; mould eradication and avoidance. The duration of all interventions in both active and c
Allergen avoidance measures within the home environment which are tailored to the child's skin prick tests, such as allergen occlusive duvet, pillow, mattress, and bed base coverings; laundering with an acaricide; drying laundry in sunlight; pest control measures and extermination; Highly Efficient Particulate Arrestance (HEPA) filter in bedroom air filter and in vacuum cleaner; smoke-free indoor environment; mould eradication and avoidance. The duration of all interventions in both active and control groups is 6 months.
Sponsors
Health Research Council of New Zealand
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
5 Years to 11 Years
Healthy volunteers
No
Inclusion criteria
Physician diagnosed asthma, parents have low income, child spends at least 5 nights of the week in one home, and who had at least one hospital admission or two unscheduled visits to the doctor, or actue medical service due to asthma in the past six months (but subjects will be delayed from entering the trial until at least 3 weeks has elapsed since their last exacerbation).
Exclusion criteria
On oral corticosteroids, other signifcant respiratory disease, andy serious chronic illness, not planning to stay in the same home for next 6 months.
Outcome results
None listed