Oxygen therapy in pneumonia

A randomised controlled trial of the effect of high flow verus titrated oxygen therapy on carbon dioxide (CO2) levels in pneumonia

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000196448

Enrollment

150

Registered

2007-04-05

Start date

2007-04-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Current standard treatment is to provide high flow oxygen to people with pneumonia. However high flow oxygen may be detrimental and few studies have looked at the use of high flow oxygen in pneumonia. An alternaitve treatment is one where the amount of oxygen received is varied depending on the oxygen level in the blood. This study compares the two treatments.

Interventions

Patients will be randomly assigned to receive oxygen regimes for 1 hour: Continuous high flow oxygen (8L/min via Hudson mask) as the intervention.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

CoughAt least one systemic feature (sweating, rigors and/or fever >37.8 C)Respiratory rate >18 breaths/min.

Exclusion criteria

Respiratory failure requiring mechanical ventilation; Diagnosis of Chronic Obstructive Pulmonary Disease (COPD)/emphysema; Acute electrocardiogram (ECG) changes suggesting ischaemia; Suspected neutropenic sepsis; Known or suspected chronic hypercapnic respiratory failure as a result of any of the following disorders - neuromuscular disease, chest wall disease, obesity hypoventilation syndrome.

Outcome results