None listed
Conditions
Brief summary
Stimulant medication can be associated with slowing of growth in children with attention deficit hyperactivity disorder (ADHD), possibly by appetite suppression mediated by hormones such as leptin and ghrelin. Twelve healthy adult volunteers will have fasting blood tests for leptin, ghrelin, insulin and glucose, with these tests repeated after a meal. This will be done twice, once on medication (dexamphetamine or methylphenidate) and once on placebo. The effect of medication on food intake and alertness will be tested, together with subjects’ assessments of appetite and medication side effects.
Interventions
Double blind randomised placebo controlled trial investigating the effect of a single dose of stimulant medication (dexamphetamine 10mg or methylphenidate 20mg) given orally to fasted healthy adult volunteers. Each subject tested with medication and placebo (calcium carbonate) to serve as their own control. Minimum wash out period 4 days.
Sponsors
Chief investigator Dr Alison Poulton
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
17 Years to 30 Years
Healthy volunteers
No
Inclusion criteria
Fit and healthy
Exclusion criteria
Current treament of medical condition, previous regular use of stimulant medication, history of substance abuse, BMI>30.
Outcome results
None listed