None listed
Conditions
Brief summary
Current standard treatment is to provide high flow oxygen to people with severe asthma. However high flow oxygen may be detrimental and few studies have looked at the use of high flow oxygen in asthma. An alternative treatment is one where the amount of oxygen received is varied depending on the oxygen level in the blood. This study compares these two treatments.
Interventions
Patients will be randomly assigned to receive one of 2 oxygen regimes for 1 hour: Continuous high flow oxygen (8L/min via Hudson mask).
Sponsors
Medical Research Institute of New Zealand
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
History of asthma; Presentation to the emergency department with an acute exacerbation of asthma; Forced expiratory volume in 1 second (FEV1) less than or equal to 50% predicted
Exclusion criteria
Diagnosis of Chronic obstructive pulmonary disease (COPD)/emphysema; Asthma attack requiring mechanical ventilation; Patient unconscious, unable to speak or unable to perform spirometry on arrival; Known or suspected chronic hypercapnic respiratory failure as a result of any of the following disorders - neuromuscular disease, chest wall disease, obesity hypoventilation syndrome.
Outcome results
None listed