None listed
Conditions
Brief summary
Osteolymphoma is a cancer of the bone marrow that responds well to radiation therapy and chemotherapy but may come back in other parts of the body. This trial will determine the results of combining radiation therapy and chemotherapy in a standardised way.
Interventions
Chemotherapy
Given Intravenously on days 1, 22, 43:
- Cyclophosphamide 750 mg per metre squared
- Doxorubicin 50 mg per metre squared
- Vincristine 1.4mg per metre squared
Prednisolone 50 mg per metre squared. Given orally for five days on each of these occassions. ie days 1-5, 22-27 etc.
A total of three 21 day cycles of chemotherapy should be administered.
Radiotherapy
should be given 3 weeks after the last cycle of chemotherapy (day 64).
Fractions should be given daily - 9-10 times per
Chemotherapy Given Intravenously on days 1, 22, 43: - Cyclophosphamide 750 mg per metre squared - Doxorubicin 50 mg per metre squared - Vincristine 1.4mg per metre squared Prednisolone 50 mg per metre squared. Given orally for five days on each of these occassions. ie days 1-5, 22-27 etc. A total of three 21 day cycles of chemotherapy should be administered. Radiotherapy should be given 3 weeks after the last cycle of chemotherapy (day 64). Fractions should be given daily - 9-10 times per fortnight. Phase I (large volume): 36Gy in 20 fractions and Phase II (small volume): 9 GY in 5 fractions to the boost volume (area of tumour that requires a boost of radiotherapy). Total dose 45 Gy in 25 fractions. Phase I and II are given over the course of one fortnight.
Sponsors
David Christie
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
17 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Histologically confirmed non-Hodgkin’s lymphoma in a bony site - Limited extraosseous disease - Ann Arbor stage IE Age >17- ECOG performance status >3 - Expected survival > 6 months - Written informed consent
Exclusion criteria
Previous radiotherapy or chemotherapy- Previous malignancy - Medically unfit to undergo treatment
Outcome results
None listed