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A randomized controlled trial of progressive resistance strength training for people with multiple sclerosis who have difficulty walking

The effects of a community based progressive resistance strength training program on the walking performance of adults with multiple sclerosis who have mild to moderate difficulties walking

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12607000101482
Enrollment
84
Registered
2007-01-31
Start date
2007-04-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Muscle weakness is common in people with multiple sclerosis (MS), and this can affect the performance of many everyday activities such as walking. A pilot study we completed showed that for people with MS weight training can lead to increased strength, improved walking ability, and improved physical functioning. Perhaps even more importantly, people in the pilot study overwhelmingly reported that they enjoyed the program because it made them feel more energetic, less disabled and more confident. This study will be the first large scientifically rigorous trial of a gymnasium-based strength training program for people with MS in the world.

Interventions

Community gymnasium based progressive resistance strength training (PRST) program. Participants allocated to the experimental group will complete a 12-week (two times per week, for 90 minutes per session), gymnasium-based strengthening program targeting the major muscle groups of the legs.

Sponsors

La Trobe University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1.Diagnosed with MS 2.have a Hauser Ambulation Index score of 2-4 (mild to moderately severe gait disability) 3.have received a medical clearance to participate in the exercise program.

Exclusion criteria

Exclusion criteria:1.an acute exacerbation of MS within two months of starting the program 2.presence of an unstable medical condition such as inadequately controlled diabetes or high blood pressure 3.the presence of any concurrent neurological condition, for example stroke 4.MS of the benign or progressive/relapsing types 5.participation in a strength training program in the six months prior to the start of the study.We will recruit both male and female participants.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026