Endocrine function following Heart Surgery in Infants less than 3 months of age.

Thyroid hormone levels and cortisol levels post congenital heart surgery in infants less than 3 months of age. Delineation of acceptable range and investigation of association with outcome.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12607000072415

Enrollment

Registered

2007-01-23

Start date

2006-07-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This observational study aims to further the understanding of how the endocrine system recovers following congenital heart surgery. Infants less than 3 months of age have more deaths and complications following congenital heart surgery than older children and adults. They have immature organ systems and may not be able to respond as rapidly as older children to the critical illness that congenital heart surgery causes. The study requires extra blood samples to be taken in addition to the routine blood tests that are taken during the recovery period in the paediatric intensive care unit. These blood samples will be obtained from indwelling lines that the patients will have in place. The test results will be analysed to delineate what an acceptable range for thyroid and adrenal hormones is in this age group following congenital heart surgery, to assess the association of low hormone levels and poor outcome measures, and to identify a group of patients for enrolment in future studies of hormone replacement.

Interventions

Thyroid and adrenal hormone concentrations decrease following congenital heart surgery, in older children this usually returns to normal after 1 week. This study will establish how quickly adrenal and thyroid hormone concentrations return to normal in infants less than 3 months of age following congential heart surgery, and whether there is any association between the amount of decrease or a delayed in adrenal / thyroid recovery and worse outcome. Nil intervention except short synacthen test for

Eligibility

Sex/Gender

All

Age

0 to 3 Months

Healthy volunteers

Inclusion criteria

Post cardiac surgery.

Exclusion criteria

Known thyroid or adrenal disease.

Outcome results