Steroids and colonic surgery

The influence of pre-operative dexamethasone on post operative recovery and fatigue in patients undergoing elective colonic resection

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000066482

Acronym

nil

Enrollment

Registered

2007-01-22

Start date

2006-06-27

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Fatigue is a common and significant problem after major colonic surgery. It is thought that one cause of this fatigue is the production of inflammatory mediators, including cytokines, in the peritoneal cavity. It is known that the production of cytokines can be decreased by the use of steroids. Thus, in order to decrease fatigue after surgery, consecutive patients undergoing major colonic surgery will be randomised to 2 groups. One will receive 8 mg of preoperative Dexamethasone (intervention group) and the other will receive saline (Placebo group). We will measure fatigue, pain, nausea and vomiting scores and measures of functional recovery after surgery in order to assess that impact of the preoperative steroid.

Interventions

8 mg of intravenous dexamethasone 90 minutes prior to incision

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Age 18 yrs and overGender : male and female

Exclusion criteria

Sensitivity to Dexamethasone or any contraindication to use of dexamethasone, long term steroid useInclusion: colonic surgery

Outcome results