None listed
Conditions
Brief summary
Injecting dye into the heart is a common investigation that helps diagnose coronary artery disease. Although it is known that small bubbles of air are often injected during this procedure and may enter the brain, they have been generally thought to be harmless. We plan to measure cognitive function before and after the heart is studied to see if these small bubbles alter brain function.
Interventions
To test whether microembolic count during left heart catheterisation (LHC) for coronary angiography (CA) or Percutaneous Coronary Intervention (PCI) is associated with cognitive change following the procedure. Patients will complete a battery of conventional and computerised neuropsychological tests preoperatively. The tests take about 1 hour to complete. The computerised battery of tests will then be administered one week, six weeks and 3 months post procedure to identify changes in cognitive f
To test whether microembolic count during left heart catheterisation (LHC) for coronary angiography (CA) or Percutaneous Coronary Intervention (PCI) is associated with cognitive change following the procedure. Patients will complete a battery of conventional and computerised neuropsychological tests preoperatively. The tests take about 1 hour to complete. The computerised battery of tests will then be administered one week, six weeks and 3 months post procedure to identify changes in cognitive function. Quality of Life (QoL), mood, Acitivities of Daily Living (ADL) and Clinical Dementia Rating (CDR) will be assessed preoperatively and 3 months post procedure. Trans Cranial Doppler (TCD) monitoring will be performed for a 15 minute epoch immediately before angiography. The signal will be recorded on audio tape for later review. Monitoring will be continuous during the angiogram. The total number of microemboli for the whole angiogram will be used for the analysis.
Sponsors
A/Prof David Scott
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Scheduled for elective LHC, who do not have neurological deficit or any contraindication to undergoing neuropsychological testing, and have given informed consent. The patients must reside in accessible proximity to the hospital to enable investigators to administer follow-up neuropsychological testing at home.
Exclusion criteria
1.Pre-existing neurological or neurovascular disease (e.g. stroke);2.A score of less than 26 on the Mini Mental State Examination 3.Anticipated difficulty with neuropsychological assessment such as: English not being the prime language; blindness; deafness;4.Geographical remoteness or medical co-morbidity that may lead to complications and loss to follow-up.
Outcome results
None listed