The Cardiac Interventions, Surgery and Cognitive Outcome (CISCO) Study

The prospective observational CISCO (Cardiac Interventions, Surgery and Cognitive Outcome) study will document the preoperative neuropsychological status of patients presenting for coronary angiography (CA) and relate this to cognitive outcomes over the succeeding three months, taking into account their management (medical; Percutaneous Coronary Intervention (PCI); or Coronary Artery Bypass Graft (CABG) surgery).

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12607000051448

Acronym

The CISCO Study

Enrollment

510

Registered

2007-01-16

Start date

2007-07-05

Completion date

2012-04-20

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The CISCO (Cardiac Interventions, Surgery and Cognitive Outcome) Study is a prospective observational cohort study of the preoperative neuropsychological status of patients presenting for CA (Coronary Angiography) and the relationship of this state with cognitive outcomes following medical, PCI (Percutaneous Coronary Intervention) or CABG (Coronary Artery Bypass Graft) surgery management of their disease.

Interventions

To test whether Mild Cognitive Impairment (MCI) prior to CA is associated with an increased risk of PPCD (Post Procedural Cognitive Dysfunction) and to compare cognitive changes between management techniques (medical; PCI; CABG surgery). Patients will complete a battery of conventional and computerised neuropsychological tests preoperatively. They will then complete the computerised test battery at 24 hours, 6 days and 3 months post intervention to identify changes in cognitive function. The t

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

Scheduled for elective CA who do not have neurological (as opposed to neuropsychological) deficit or any contraindication to undergoing neuropsychological testing, and have given informed consent. The patients must reside in accessible proximity to the hospital to enable investigators to administer neuropsychological testing at home.

Exclusion criteria

i. Pre-existing neurological or clinically evident neurovascular disease (e.g. TIA, stroke);ii. Dementia: a score less than 26 on the Mini Mental State Examination (MMSE) or CDR > 1;iii. Anticipated difficulty with neuropsychological assessment such as: English not being the prime language; blindness; deafness;iv. Geographical remoteness or medical co-morbidity that may lead to complications and loss to follow-up.

Outcome results