Anaesthesia Cognitive Evaluation (ACE) Study

The prospective, descriptive ACE (Anaesthesia Cognitive Evaluation) Study will identify whether preoperative cognitive impairment (Mild Cognitive Impairment (MCI)) increases the risk of PostOperative Cognitive Dysfunction (POCD) in elderly patients undergoing non-cardiac surgery (elective Total Hip Replacement (THR)) compared to a concurrent control group of medically managed patients with osteoarthritis (OA).

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12607000049471

Acronym

The ACE Study

Enrollment

365

Registered

2007-01-16

Start date

2007-08-03

Completion date

2013-01-14

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The ACE (Anaesthesia Cognitive Evaluation) Study is a prospective descriptive comparison of the prevalence of MCI (Mild Cognitive Impairment) and the incidence of POCD (Post Operative Cognitive Dysfunction) in patients undergoing THR (Total Hip Replacement) for OA (Osteoarthritis) and a control group of patients who have OA (Osteoarthritis) that is managed medically.

Interventions

To test whether MCI increases the risk of POCD following THR and to compare the change in cognitive function in patients undergoing THR for OA with a control group of patients who have OA that is managed medically. Medical management will be the use of anti-inflammatory medications as clinically indicated and prescribed by the treating physician. Patients will complete a battery of conventional and computerised neuropsychological tests preoperatively, and at 6 days, 3 months and 12 months post-operatively. The conventional battery is a set of eight paper and pencil tests (eg. trail making tests A and B, digit symbol test, Rey Auditory Verbal Learning test) and the computerised battery is a version of Cogstate®. The tests take about 1 hours to complete. Quality of Life (QoL), mood characteristics, Activities of Daily Living (ADL) and Clinical Dementia Rating (CDR) will be assessed preoperatively and 3 and 12 months post-operatively.

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

Scheduled for elective hip replacement surgery for osteoarthritis or control patients with medically managed osteoarthritis who: do not have neurological deficit; give informed consent; have no contraindication to neuropsychological testing. The patients must reside in accessible proximity to the hospital to enable investigators to administer baseline neuropsychological testing at home.

Exclusion criteria

1.Pre-existing neurological or clinically evident neurovascular disease (e.g. TIA, stroke);2.Score of less than 26 on the Mini Mental State Examination or CDR>1 (i.e. exclude dementia);3.Anticipated difficulty with neuropsychological assessment, such as English not being the prime language, blindness, deafness;4.Associated medical problems that may lead to significant complications and subsequent loss to follow-up (ASA Physical Status IV or higher);Geographical remoteness that may make it difficult to test patients at home.

Outcome results