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Stroke Attention Rehabilitation Trial (START): Impact of Attention Process Training (APT) on Attention and Quality of Life

A randomised phase III study to evaluate the effectiveness of Attention Process Training (APT-I) in reducing attention deficits in people who recently suffered a stroke

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12607000045415
Acronym
START
Enrollment
78
Registered
2007-01-12
Start date
2007-01-15
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Approximately half of all individuals who have a stroke experience subsequent cognitive difficulties (e.g., memory, attention). Yet, post-stroke rehabilittaion has traditionally focussed on physical therapy and speech/language rehabilitation, with relatively little focus on improving the most common cognitive problem after stroke - impaired attention. Attention problems have a negative impact on functional outcomes (e.g., quality of life). There is evidence from several small studies, mostly in people with Traumatic brain Injury, that attention training can positively impact on functional outcomes. This randomised controlled trial will examine the effectiveness of implementing an attention rehabilitation programme, Attention Process training (APT-I) , by comparing two groups of persons who have recently suffered a stroke: those who recieve APT, and those who recieve standard care. Outcome measures will include attention deficits and other neuropsychological impairments, quality of life, levels of disability and handicap, and cost-effectiveness of the intervention.

Interventions

This randomised controlled trial will examine the effectiveness of implementing an attention rehabilitation programme, Attention Process Training I (APT- I), by comparing two groups of persons who have recently suffered a stroke: those who receive APT with those who receive standard care. Those who recieve APT will also recieve standard care. Average duration of standard care is 3 weeks. APT materials consist of a group of hierarchically organised tasks that exercise different components of atte

This randomised controlled trial will examine the effectiveness of implementing an attention rehabilitation programme, Attention Process Training I (APT- I), by comparing two groups of persons who have recently suffered a stroke: those who receive APT with those who receive standard care. Those who recieve APT will also recieve standard care. Average duration of standard care is 3 weeks. APT materials consist of a group of hierarchically organised tasks that exercise different components of attention, including sustained, selective, alternating, and divided attention. As an individual moves through the program the tasks place increasing demands on complex attention control. The program activities are not functional and resemble laboratory tasks. This is because most functional tasks (e.g., meal planning) are multifaceted and require activation of many different cognitive processes. Use of discrete attention tasks allows stimulation of isolated components of attention. Examples of APT activities identified by the authors of the intervention, Sohlberg and Mateer, that correspond to the different facets of attention are: (1) Sustained Attention: listening for target words or sequences within an array and pressing a button when the target is identified, listening to paragraphs and showing comprehension of content, and mental arithmetic; (2) Alternating Attention: Exercises that require listening for one type of target word or sequence and then switching to listening for a different type of word or sequence mid-way through the task, paper-and–pencil tasks that require alternating between generating numbers and letters that come before or after a presented target,; (3) Selective attention: Completion of sustained attention tasks with the addition of distractor noise or movement, completion of paper-and-pencil tasks with the addition of visual distracters (i.e., transparent overlays); (4) Divided Attention: reading paragraphs for comprehension while simultaneously scanning for a target word (i.e., counting the number of times “and” appears), completing a sustained attention activity while simultaneously tracking elapsed time. A maximum of 30 hours of APT is to be provided in one-to-one sessions daily (weekdays). Sessions will occur once daily and be 90 minutes in length (with a mid-session break) and be conducted over 4 weeks. Clients are typically discharged after 3 weeks of inpatient rehabilitation. Those discharged before the end of the APT intevention will be followed-up for treatment and assessment at place of discharge. Standard care includes daily sessions of occupational and physiotherapy, and other therapies (e.g., speech therapy) as required, and will be provided to both groups. In order that the provision of any other interventions that impact attention can be determined, all other rehabilitation interventions provided will be monitored in both groups until the end of the study (i.e., 6-months post-randomisation).

Sponsors

Clinical Trials research Unit, faculty of Medical and Health Sciences, University of Auckland
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1.Newly diagnosed stroke (first-ever-in-a-lifetime stroke)2.Attention Deficit identified (defined as Bells test has at least 3 errors; PASAT or Trails A or Trails B = 0.5 [i.e. half a SD below the mean]; or IVA-CPT attention quotient, visual attention quotient or auditory quotient is = 90 [i.e 1 SD below Z -1.0 or Q < 90]). 3.Fluent in English (can converse, as standardised administration of tests requires English fluency).

Exclusion criteria

1.Cognitive deficit precluding participation precluding participation in APT (Mini-Mental State Examination Score < 20 );2.Unable to give informed consent; 3.Not considered medically stable (e.g., kidney/heart failure) in the opinion of a medical clinician (i.e., not referred for rehabilitation); 4.Known to have another condition that could impact assessment findings or ability to complete APT (e.g., drug abuse, alcoholism, mental illness) in the opinion of a medical clinician;5.Participation in another study that, in the opinion of the investigator, may affect cognitive performance or add significantly to participant burden.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026