Investigation into the treatment of Female Pattern Hair Loss

Double blind placebo controlled trial into the the treatment of female pattern hair loss with spironolactone and minoxidil.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12607000027415

Enrollment

150

Registered

2007-01-11

Start date

2007-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Pilot studies show that spironolactone is effective in the arrest of female pattern hair loss and may result in some hair gain. However to date there have been no placebo controlled trials to verify this. As well minoxidil has been shown to be efficacious in the treatment of female pattern hair loss and there are recent case reports that it may have a synergistic effect when used with spironolactone. This project aims to study the effectiveness of these treatments as well as determining underlying tissue and genetic factors that may effect response.

Interventions

2 randomly allocated intervention groups: spironolactone and topical placebo treatment sprionolactone and topical minoxidil spironolactone will be admisnistered at a dose of 200mg once daily orally and 2% topical minoxidil will be used as 1ml bd topical the duration of treatment is 12 months

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

Diffuse hair loss of greater than 6 months, with at clinical diagnosis of female pattern hair loss-Biopsy proven follicle miniaturization (terminal/villus = 4:1).-Treatment naïve.

Exclusion criteria

Contraindications to minoxidil or spironolactone-other causes of hair loss.

Outcome results