None listed
Conditions
Brief summary
This study will investigate two methods of pain relief after caesarean section conducted under regional anaesthesia. Our hypothesis is that multimodal analgesia including intrathecal morphine is more effective than multimodal analgesia with regular administration of oral opioid.
Interventions
Intervention group: Intrathecal morphine 100 mcg given with spinal anaesthesia immediately preoperatively. Both control group and intervention groups also receiving oral paracetamol 1 g in recovery and 6 hourly until 24 hours postoperatively plus diclofenac 100 mg per rectum at completion of surgery and diclofenac 50 mg
Intervention group: Intrathecal morphine 100 mcg given with spinal anaesthesia immediately preoperatively. Both control group and intervention groups also receiving oral paracetamol 1 g in recovery and 6 hourly until 24 hours postoperatively plus diclofenac 100 mg per rectum at completion of surgery and diclofenac 50 mg orally 8 hourly until 24 hours postoperatively, after caesarean section.
Sponsors
Individual (Michael Paech)
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Elective or non-elective caesarean section under combined spinal-epidural or spinal anaesthesia American Society of Anesthesiologists classification 1 or 2
Exclusion criteria
Preoperative opioid useContraindication, allergy or known intolerance to study drugsPreoperative nausea or pruritusFailure to identify the subarachnoid space or accidental dural puncture with the epidural needleRequirement for intraoperative opioid or epidural analgesic other than local anaesthetic Conversion to general anaesthesia.
Outcome results
None listed