Efficacy of Vitamin C treatment for children with Charcot-Marie-Tooth disease type 1A

Efficacy of ascorbic acid supplementation in children with Charcot-Marie-Tooth disease type 1A to improve muscle strength and peripheral nerve function

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000481572

Acronym

vitCmt

Enrollment

Registered

2006-11-23

Start date

2007-01-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this trial is to determine the effect of high-dose vitamin C on muscle strength, nerve function, gross motor coordination and health-related quality of life in children with Charcot-Marie-Tooth disease type 1A. We hypothesise that muscle strength, nerve function, gross motor coordination and health-related quality of life will be greater in children with Charcot-Marie-Tooth disease type 1A who receive dietary vitamin C supplementation compared to children receiving the placebo.

Interventions

Experimental group: Daily oral ascorbic acid supplementation for 12 months as per the established age-specific tolerable upper intake levels of ascorbic acid (US Food and Nutrition Board Institute of Medicine, 2000).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

2 Years to 16 Years

Healthy volunteers

Inclusion criteria

Diagnosis of Charcot-Marie-Tooth disease type 1A.

Exclusion criteria

Pregnancy; glucose-6-phosphate dehydrogenase deficiency; hereditary hemochromatosis; thalassemia; polycythemia; leukaemia or sideroblastic anaemia; sickle cell anaemia; acute foot injuries and recent foot surgery; inflammatory arthritis; diabetes.

Outcome results