Vitamin D Time-Course Pilot Study

Time-course of parathyroid hormone change following vitamin D supplementation in vitamin D insufficient elderly: a pilot study.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000434594

Acronym

Nil

Enrollment

Registered

2006-10-10

Start date

2005-10-27

Completion date

2006-05-16

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Elderly volunteers recruited from Older People’s Health wards at Auckland Hospital and randomly assigned to one of three active vitamin D3 treatment regimens. Blood measurements are collected at two monthly intervals and lifestyle and body composition measurements made at baseline and at the end of the study.

Interventions

One of three doses of oral calciferol (Vitamin D3): 1. 500 000 iu followed by monthly placebo for 8 months. 2. 500 000 iu followed by monthly 50 000 iu for 8 months. 3. 50 000 iu monthly for 9 months.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

Able to provide informed consent and have a high risk of vitamin D insufficiency.

Exclusion criteria

Renal insufficiency (creatinine clearance < 20 ml/min).Major bone disorder, condition or drugs likely to affect calcium, parathyroid hormone or vitamin D metabolism.On high dose vitamin D or long-term steroids.Major systemic illness with a prognosis of 6 months or less.

Outcome results