None listed
Conditions
Brief summary
Younger subjects with type 1 diabetes are being encouraged to undertake exercise, with no limitation on type/intensity of exercise (providing that there are no complications of diabetes present, e.g. cardiovascular disease), however, there is very little scientific information on the response of those with type 1 diabetes to intense exercise, and almost no studies on the response of these patients to high intensity exercise training. This study aimed to compare the metabolic (e.g. blood and muscle lactate, blood glucose) and ionic responses (e.g. muscle sodium potassium adenosine triphosphatase, blood potassium, blood acidosis) during high intensity exercise, as reflected in samples of blood, muscle, and expired gas analysis, in younger people with and without type 1 diabetes; and secondly to evaluate the responses of both groups to high intensity exercise training. We hypothesised that acute exercise responses would be similar in the subjects with and without type 1 diabetes; and that high intensity exercise training would improve metabolic and ionic responses during high intensity exercise in subjects with type 1 diabetes; and would not result in deterioration of overall metabolic control (reflected by glycosylated haemoglobin).
Interventions
7 weeks of high-intensity cycle sprint training: 3 sessions per week; 4 x 30 second sprints with 4 minutes rest in Week 1; incremented by 2 sprints per session per week in Weeks 2, 3, and 4, then rest period reduced to 3 minutes with 10 sprints per session in Weeks 5, 6, and 7 - session duration between 30 - 60 minutes, according to week of training.
Sponsors
Dr Alison Harmer
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
Group with type 1 diabetes, inclusion: diabetes for at least 1.5 yrs; taking no medications other than insulin; no evidence of diabetic complications such as proliferative retinopathy (>10 microaneurysms in previous year) or autonomic or peripheral neuropathies; HbA1c < 10%. Non-diabetic control group, inclusion: no history or family history of any metabolic disorder. Both groups, inclusion: not currently undertaking high-intensity exercise training; non-smokers; no medications.
Exclusion criteria
Group with type 1 diabetes, exclusions: taking mediaction other than insulin; HbA1c >10%; presence of diabetic complications; diabetes for < 1.5 years. Non-diabetic control group, exclusions: taking medication; family or personal history of metabolic disorders.
Outcome results
None listed