None listed
Conditions
Brief summary
To discover if the consumption of foods made from CSIRO barley leads to changes in the levels of substances in the plasma (such as cholesterol) that would suggest they are beneficial for heart health.
Interventions
All participants at the start of the study will be on a fat controlled diet for 2 week prior to being randomised to 1 of 2 treatments of 6 weeks duration each & crossed over at the end of each 6 weeks to the alternative. The treatments are either test foods (cereal, bread muffins) containing either barley flour or wholemeal wheat flour. There is no wash-out period between treatments.
Sponsors
Commonwealth Scientific Industrial Research Organisation, Human Nutrition
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Have a fasting plasma triglyceride concentration greater than 1.7mmol/L but less than 4.0 mmol/L, and/or plasma cholesterol greater than 5.5 mmol/L.Are taking cholesterol-lowering drugs provided the dose of medication remains stable for the duration of the study.
Exclusion criteria
:Have a definite or suspected personal or family history of adverse events or hypersensitivity to barley or wheat (eg. coeliac disease)Suffer from bleeding disordersAre considered by the doctor or dietitian to be unwilling, unlikely or unable to comprehend or comply with the study protocolHave participated in another research study within 30 days preceding the commencement of this studyHave a history or presence of gastrointestinal, renal or hepatic disease of any causeAre taking any medication or food that is likely to affect the plasma cholesterol such as laxatives containing psyllium, antibiotics, probiotics or sterol-containing margarines.
Outcome results
None listed