None listed
Conditions
Brief summary
The aim of this study is to evaluate the effectiveness of adding D-Cycloserine to group-based exposure therapy for panic disorder. It is hypothesised that individuals who receive D-Cycloserine and exposure therapy will attain a greater reduction in panic symptoms in comparison to individuals who receive placebo and exposure therapy. Participants from the community who have a primary diagnosis of panic disorder will receive three group based exposure therapy sessions in combination with placebo or D-Cycloserine. Exposure therapy consists of exposure to feared body sensations. Panic symptoms are assess one and three months later. All therapsists, assessors, and individuals entering data are blind to drug condition.
Interventions
D-Cycloserine and Exposure Therapy. Participants are given 3 weekly sessions (once per week) of group-based exposure therapy. One group of participants receives D-Cycloserine (50mg) before each therapy session. Each dose is given orally in capsule form once before each of the three therapy sessions.
Sponsors
University of New South Wales
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Primary diagnosis of Panic Disorder.
Exclusion criteria
Epilepsy, severe kidney disease, use of contraindicated medications, suicide intent, substance dependence and pregnancy.
Outcome results
None listed