None listed
Conditions
Brief summary
Meals rich in saturated fat increase postprandial levels of pro-inflammatory cytokines in subjects with type 2 diabetes and to a lesser degree in healthy subjects. In the present study we aimed to compare the effect of meals rich in saturated fat and monounsaturated fat and meals rich in bran and potato on pro-inflammatory cytokines and interleukin-8 in obese and nonobese subjects. Frequent acute increases in levels of pro-inflammatory cytokines as a result of regularly eating meals rich in saturated fat may increase the risk of developing diabetes particularly in obese subjects. The principal investigators, data analyst and laboratory staff were blinded to the meal allocation.
Interventions
Administered 5 meals. Meal A, dehydrated potato (40 g); Meal B, dehydrated potato (40 g) plus saturated fat (1.6 g cream/kg body weight); Meal C, dehydrated potato (40 g) plus canola oil (0.6 g/kg body weight), Meal D, dehydrated potato (40 g) plus olive oil (0.6 g/kg body weight); Meal E, wheat bran (44 g) plus 40 ml trim milk. The meals all contained 2 cooked eggs. The potato was hydrated by addition of hot water. The meals were administered to an individual at the rate of one per week for
Administered 5 meals. Meal A, dehydrated potato (40 g); Meal B, dehydrated potato (40 g) plus saturated fat (1.6 g cream/kg body weight); Meal C, dehydrated potato (40 g) plus canola oil (0.6 g/kg body weight), Meal D, dehydrated potato (40 g) plus olive oil (0.6 g/kg body weight); Meal E, wheat bran (44 g) plus 40 ml trim milk. The meals all contained 2 cooked eggs. The potato was hydrated by addition of hot water. The meals were administered to an individual at the rate of one per week for 5 weeks. The subjects consumed the meals in the early morning (0800-0830 h). The total study period for an individual was 5 weeks.
Sponsors
National Heart Foundation of New Zealand
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
BMI >=30 kg/m2 and waist circumference >=90 cm for men and >= 88 cm in women. BMI =20-25 kg/m2 and waist circumference < 90 cm for men and <88 cm for women.
Exclusion criteria
Cigarette smoking; history of cardiovascular disease; chronic infections; serious illnesses; use of medications including hormone replacement therapy. Women using the contraceptive pill and subjects with features of the metabolic syndrome including hypertension and dyslipidaemia will not be excluded.
Outcome results
None listed