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Australasian Carbohydrate Intolerance Study in Pregnancy

Australasian Carbohydrate Intolerance Study in Pregnancy

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12606000294550
Acronym
ACHOIS
Enrollment
1000
Registered
2006-07-11
Start date
1993-09-02
Completion date
2003-06-30
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Gestational impaired glucose tolerance, associated with subsequent maternal non-insulin dependent diabetes, is routinely screened for during pregnancy, despite the lack of consensus as to the value of such screening and the subsequent management. Epidemiological studies suggest maternal and perinatal morbidity, often attributed to glucose intolerance in pregnancy, is more likely to be due to the effects of maternal age, maternal obesity or the knowledge of the diagnosis and the consequences of subsequent management. The aim of this multicentre study is to assess two forms of antenatal care in women with impaired glucose tolerance; routine antenatal care with 'diabetic style care'. The primary outcomes relate to important perinatal and maternal morbidity. The results will help answer the question as to whether substantial resources should be applied to the diagnosis and management of glucose intolerance in pregnancy. This trial assesses two forms of care for treating women with glucose intolerance of pregnancy.

Interventions

Glucose Intolerance Group: Routine obstetrics care by the attending obstetric team, dietary advice, glucose monitoring and insulin therapy as needed Study continued until recruitment was completed, final follow up was 3 months postpartum.

Sponsors

Prof Caroline Crowther
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No

Inclusion criteria

Singleton or twin pregnancy with a positive Glucose Challenge Test (GCT) or risk factors for Gestational Diabetes Mellitus (GDM) at 16-30.0 weeks gestation and at 24-34.6 weeks gestation, an Oral Glucose Tolerance Test (OGTT) result: fasting <7.8mmol/L and 2 hour > or equal to 7.8mmol/L and < or equal to 11.0mmol/L.

Exclusion criteria

Previously treated Glucose Intolerance in Pregnancy or Gestational Diabetes, Chronic active systemic disease (excluding essential hypertension), Diabetes, Gestational Diabetes OGTT result (fasting > or equal to 7.8mmol/L and/or 2 hr > or equal to 11.1mmol/L), Glucose Intolerance in Pregnanct detected in current pregnancy before 20 weeks.

Outcome results

None listed

Source: ANZCTR · Data processed: Apr 6, 2026