None listed
Conditions
Brief summary
Subjects with mild to moderate obstructive sleep apnoea will be invited to participate in a supervised 4-month diet and exercise program. We will measure daytime function, quality of life and severity of sleep-disordered breathing before and after the study, and in addition will followup subjects for 12 months after they complete the active intervention protocol.
Interventions
The following interventions are implemented together for 4 months:
1. Diet - using very low energy liquid meal replacement (Optifast) in combination with low fat and low carbohydrate meals.
2. Exercise - both aerobic using exercise bikes and resistance using weights in a hospital gym, as well as at home. The hospital based sessions are for 40 minutes to 1 hour, 3 times each week for 8 weeks then once each week for 8 weeks. In addition, subjects are asked to exercise at home for 30-60 minutes on
The following interventions are implemented together for 4 months: 1. Diet - using very low energy liquid meal replacement (Optifast) in combination with low fat and low carbohydrate meals. 2. Exercise - both aerobic using exercise bikes and resistance using weights in a hospital gym, as well as at home. The hospital based sessions are for 40 minutes to 1 hour, 3 times each week for 8 weeks then once each week for 8 weeks. In addition, subjects are asked to exercise at home for 30-60 minutes on the days that they do not attend the hospital gym. There are no drugs involved.
Sponsors
Institute for Breathing and Sleep
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
AHI at least 10waist circumference at least 95cm in females, 100cm in males.
Exclusion criteria
Physical or psychological co-morbiditiesInability to exerciseDietary restrictionsInsulin requiring diabetesRenal or liver disease.
Outcome results
None listed