Dreaming and EEG changes during anaesthesia maintained with propofol or desflurane

The incidence of dreaming and the nature of electroencephalographic (EEG) changes during anaesthesia maintained with propofol or desflurane

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000279527

Acronym

GENIE II

Enrollment

300

Registered

2006-07-04

Start date

2006-08-16

Completion date

2009-02-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Dreaming is commonly reported after anaesthesia. There is some evidence that dreaming is more likely to be reported after anaesthesia maintained with propofol than anaesthesia maintained with desflurane. In this study, we will randomise patients having non-cardiac surgery to anaesthesia with propofol or desflurane and will measure the incidence of dreaming. Post-operative observers will be blind to group allocation (propofol or desflurane)

Interventions

Control = continuous intravenous propofol infusion for maintenance of anaesthesia. Duration of administration and total dose will depend on duration of surgery.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

Presenting for relaxant general anaesthesia for non-cardiac surgery. Expected to be available for immediate postoperative interview.

Exclusion criteria

Patients with inadequate English language comprehension or major drug abuse problems.

Outcome results