The cardiac and respiratory response to recruitment maneuvers (RM) in ventilated patients with acute lung injury.

The cardiac and respiratory response to a stepwise recruitment maneuver in ventilated patients with acute lung injury.

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000268549

Enrollment

Registered

2006-06-29

Start date

2007-03-17

Completion date

2008-09-24

Last updated

2024-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To look at the response of the heart and lungs to a procedure where the pressure delivered by a mechanical ventilator is increased to increase the level of oxygen delivered to a patient. Subjects are blinded.

Interventions

Recruitment maneuver(RM) - before and after. The RM is a stepwise increase in positive end exiratory pressure (PEEP) level from baseline to 40cm H20, with 2 minutes at each PEEP level and then reduced slowly to optimal PEEP (as determined by the SaO2)The RM will last for 10 minutes with no control. Measurement will be made before and after the one intervention (RM) in all subjects.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

Ventilated, with ALI/ARDS.

Exclusion criteria

ICC with air leak, pneumothorax, asthma, unstable haemodynamics eg. MAP < 60 mmHg.

Outcome results