None listed
Conditions
Brief summary
The screening program with flexible sigmoidoscopy has been operating for 10 years. Up to 40% of participants do not reattend, largely due to concerns over pain and discomfort and our data indicates that high pain scores and poor bowel cleansing are associated with reduced detection of colonic adenomas. We aim to assess the efficacy of peppermint oil in improving adenoma detection by reducing pain. Additionally, the efficacy of two enemas rather than the standard one enema in improving bowel cleansing and adenoma detectionwill be assessed. Participants, the procedualist, staff interviewing subjects after sigmoidoscopy and the data analyst are blinded to the nature of the interventions. Study will be unblinded following adequate recruitment
Interventions
All attenders at a flexible sigmoidoscopy based colorectal cancer screening group are invited to participate in this substudy. Participants are randomly allocated to receive a peppermint oil capsule taken orally at least 30 minutes prior to undergoing sigmoidoscopy. Additionally, the same participants are randomly allocated t
All attenders at a flexible sigmoidoscopy based colorectal cancer screening group are invited to participate in this substudy. Participants are randomly allocated to receive a peppermint oil capsule taken orally at least 30 minutes prior to undergoing sigmoidoscopy. Additionally, the same participants are randomly allocated to recieve one (standard care) or two phosphate enemas per rectum as bowel preparation also at least 30 minutes prior toprior to sigmoidoscopy. Both interventions are single administrations only on the day of sigmoidoscopy.
Sponsors
Dr Charlie Viiala
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All participants of a flexible sigmoidoscopy based colorectal cancer screening program.
Exclusion criteria
If allergy to peppermint oil, severe symptomatic gastro-oesophageal reflux disease, use of any analgesics on the day of the sigmoidoscopy prior to the procedure.
Outcome results
None listed